Cogan-Reese syndrome is a clinical variant of iridocorneal endothelial (ICE) syndrome (see this term) characterized by variable iris atrophy, pigmented and. This variant of ICE syndrome is distinguised by its Cogan-Reese sub-type of ICE syndrome. A YEAR-OLD woman was first diagnosed as having iridocorneal endothelial syndrome in She underwent a trabeculectomy in Photographs first.

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The edema can be microcystic, even with a normal intraocular pressure this is common of all three variants. However, prompt diagnosis is important given the progressive nature and syndrom course of ICE.

The purpose is to present a case of iridocorneal endothelium Syndrome with glaucoma and discuss clinical presentation and management strategies.

Cogan-Reese Syndrome. | Cornea | JAMA Ophthalmology | JAMA Network

All had peripheral anterior synechias. Information on current clinical trials is posted on the Internet at www. Sign in to access your subscriptions Sign in to your personal account. Iris nevus Cogan-Reese syndrome. Cogan-Reese syndrome xogan one of the iridocorneal endothelial ICE syndromes, all of which usually affect one eye of young to middle-aged women. Testing and Imaging Making the diagnosis of an ICE syndrome is often challenging, as it can appear similar to other disease states, including posterior polymorphous corneal dystrophy.


Detailed information Professionals Summary information Greekpdf. All three disease entities are difficult to treat given their progressive nature and the obliteration of the iridocorneal angle reesd leads to refractory elevation in IOP.

Comparisons may be useful for a differential diagnosis:.

Sign in to customize your interests Sign in to your personal account. Purchase access Subscribe now. Laser surgery is rarely effective. Unilateral use of prostaglandin analogue e.


Glaucoma may occur as a secondary disorder to Cogan-Reese syndrome. Page Discussion View form View source History. Central Humphrey visual field, OU. Get free access to newly published articles Create a personal account or sign in to: Only comments written in English coga be processed. Web Privacy Policy Synxrome Statement. Oldham, MD All contributors: Pre-operatively, the patient was given mannitol due to her severely elevated IOP.

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Iridocorneal Endothelial Syndrome and Secondary Glaucoma

CS is one of three syndromes affecting the eyes progressive iris atrophy and Cogan-Reese syndrome are the other two that make up the iridocorneal endothelial syndrome ICE syndrome.

Loss of the normal iris crypts leads to a smooth-appearing iris. Investigational Therapies Information on current clinical trials is posted on the Internet at www. Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. Sign in to download free article PDFs Sign in to access your subscriptions Sign in to your personal cgan. Others suggest that the primary disorder involves the cells that line the cornea corneal endotheliumwith the impact on the iris as a secondary or associated disorder.

Create a free personal account to download free article PDFs, sign up for alerts, and more. Corneal clarity is often compromised in Cogan-Reese patients.

Optical coherence tomography characteristics of the iris in Cogan-Reese syndrome. However, a ‘functional’ angle-closure that can be confused with open-angle glaucoma may syndrpme because the endothelial cell membrane can advance without causing overt synechial formation.


This disorder most frequently appears in young and middle-aged females, usually affecting only one eye unilateral and developing slowly over time. Iridocorneal Endothelial Syndrome ICE syndrome is a unique ophthalmic disorder that involves an irregular corneal endothelium that can lead to varying degrees of corneal edema, iris atrophy, and secondary angle-closure glaucoma.

Series of 7 cases] J Fr Ophthalmol.

Cogan Reese Syndrome – NORD (National Organization for Rare Disorders)

Stereo disc photographs and visual field sybdrome Humphrey or Goldmannalong with optic nerve and nerve fiber layer assessment heidelberg retinal tomogram HRT or optical coherence tomography OCTcan all be implemented in the initial work-up and ongoing evaluation for glaucoma progression in these patients.

When medical therapy is unsuccessful at controling IOP, surgical therapy with a filtering procedure may be necessary. Comparisons may be useful for a differential diagnosis: Routine evaluation for glaucoma in these patients should be done by measuring intraocular pressure and evaluating the angle for PAS with gonioscopy. The patient was pseudophakic OU.

Cogan-Reese Syndrome

It presents as a unilateral disease, more common in women, between the ages of 20 and Sign in to make a comment Sign in to your personal account. In the early stages, the angle may appear open clinically although it is covered by this transparent membrane.

The role of prostaglandin analogs, which reduce intraocular pressure by enhancing uveoscleral outflow, remains unclear. Facts about the Cornea and Corneal Disease.

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